In vitro assessment of scaffolds for bone repair

Several naturally-derived and synthetic porous scaffolds from national and international collaborators have undergone in vitro assessment using primary human bone cells (Fig 3). It is anticipated that these will move through to in vivo evaluation in a pre-clinical model. 3D Printing of nano-composite scaffolds and 3D Biofabrication of hydrogel bio-inks encapsulating bone marrow-derived stem cells have been developed (Figs 4 and 5) for bone regeneration which are undergoing in vitro characterisation.

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Figure 3: Human Bone Cells growing on a scaffold.
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Figure 4: 3D Biofabrication of Gelatin-MA hydrogel construct containing bone marrow stem cells
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Figure 5: 3D Printing of anatomically shaped cartilage-bone constructs

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