In vivo assessment of scaffolds for rotator cuff repair
UoA have used an in vivo model to successfully test two biomaterials from commercial partners, developed within New Zealand and the UK. We have also identified a collagen scaffold developed by the Ophthalmology Department, UoA, which is currently being patented for use in tissue regeneration (Fig 6). We are assessing this in our in vivo rotator cuff model and expect to report outcomes by the end of this year.
Figure 6: Collagen scaffold (printed with permission from: Dr Dipika Patel, Ophthalmology, University of Auckland). A) Scanning electron micrograph B) fluorescent micrograph.
The Regenerative Medicine flagship programme aims to use biofabrication techniques, in-depth biological knowledge and expertise in a range of assessment tools to translate outcomes from promising research platforms into marketable therapeutic products. Throughout these milestones we constantly interact with clinicians and commercial entities within New Zealand and internationally. This platform research has strong people development, not only are we producing a platform for orthopaedic research training but also multidisciplinary biologists and bioengineers. We are using established basic principles and methodologies to perform this research and not developing new basic science. It is indeed translational research.